• Novak Djokovic, chasing grand slam, will play a qualifier
• Champion Naomi Osaka could face Kerber in third round
Andy Murray may be hoping to build some rhythm and establish a run of matches at the US Open this year, but he will start with one of the toughest first-round draws possible as he faces Stefanos Tsitsipas of Greece.
The pair have never faced each other. Tsitsipas, seeded third and beaten in the French Open final in June by Novak Djokovic, is part of the second tier of tournament favourites, behind the Serb.
Related: Serena Williams withdraws from US Open with hamstring not healed