Manchester City are in “big, big trouble” with injuries and player fatigue, the manager of the defending EPL champion, Pep Guardiola, has said.The Spaniard has been without defenders Kyle Walker and Nathan Ake in recent matches, while impeccable Rodri said he ‘needs a rest’ after the midweek draw at Real Madrid in the Champions League.”I need to rest the centre-halves also but in (England’s) friendly games, (John Stones and Kyle Walker) got injured so they get cannot rest,” Guardiola said on Friday, ahead of City’s Premier League clas with Luton Town.##NAJAVA_MECA_8028179##”We are in big, big trouble. I had the feeling we were tired in the last games. We will decide tomorrow what we have to do.”Ake, Walker and Phil Foden all remain fitness doubts for Saturday, with Guardiola adding: “We’re training this afternoon and then we’ll know better how they feel.”##EDITORS_CHOICE##Spain international Rodri has played 3,498 minutes for City across all competitions this season. Only Foden (3,560 minutes) has played more. “Sometimes, it is what it is,” Rodri said on Tuesday. “I need to adjust. It (rest) is something we are planning, yeah.”Asked about Rodri’s importance to City, Guardiola said: “Take a look at our games and you realise. It is simple. He is so important for the quality he gives us. But if you have a player that doesn’t want to play, he won’t play.”ENGLISH PREMIER LEAGUE – MATCHDAY 33Saturday 14:30: (2.80) Newcastle (3.60) Tottenham (2.40)17:00: (1.45) Brentford (4.80) Sheffield Utd (8.00)17:00: (2.20) Nott.Forest (3.45) Wolverhampton (3.25)17:00: (1.10) Man.City (11.0) Luton (18.0)17:00: (3.40) Burnley (3.50) Brighton (2.10)19:30: (2.60) Bournemouth (3.40) Man.Utd. (2.70)Sunday 16:00: (2.35) West Ham (3.50) Fulham (2.95)16:00: (1.22) Liverpool (6.50) Crystal Palace (12.0)18:30: (1.30) Arsenal (5.80) Aston Villa (9.00)Monday 22:00: (1.70) Chelsea (3.70) Everton (5.10)***odds are subject to change***